Don Blair set the CIS world on fire in 1995. He led the Calgary Dinos to a Vanier Cup championship scoring four touchdowns in the big game a 54-24 victory over the Western Mustangs at Skydome. He would be named the top player in Canadian University Football capturing the Hec Crighton award. CFL General Managers were buzzing about Blair's potential as a professional with unprecedented speed and hands in the CIS. The Ottawa native would be drafted by the Edmonton Eskimos 1st overall in the 1996 entry draft. Before going to Edmonton he would pursue a free agent tryout with the Chicago Bears which was ultimately unsuccessful. Following his sojourn to the NFL Blair reported to Edmonton at midseason and provided a spark as a special teams ace primarily as a punt returner.
In his rookie season he had an 81 yard punt return for a touchdown while seeing limited action as a receiver. in 1997 and 1998 he began to emerge as a star receiver. In 1998, his final season with Edmonton he broke the 1,000 yard receiving mark with 1,091 yards and 6 touchdowns. The breakthrough season and his pending free agency meant that he was in high demand as a star offensive player with a non-import status. The B.C. Lions would ultimately come out on top in the bidding war signing Blair. With Damon Allen as his quarterback Blair would enjoy 2 productive seasons in 1999 and 2000 totaling 9 receiving touchdowns over the 2 years. The 2000 season would be capped with a Grey Cup victory as the Lions upset the favoured Montreal Alouettes. His final season with BC in 2001 was plagued with injuries as he played in only 5 games. He would again be a free agent for the 2002 season and elected to return to the site of his amateur glory in Calgary this time with the Stampeders.
Blair would have 2 productive seasons as a Stampeder before retiring after the 2003 season. Don Blair parlayed his outstanding collegiate success into a solid 8 season career as a professional in the CFL.